Abstract
Maciej Kusztal - 6th year medi
Abstract
Soluble ST2 (sST2) has been linked with cardiovascular disease and has an important value as a predictor of hospitalization, short-term mortality risk, and death. Normal pregnancy, especially third trimester, was associated with a mild systemic inflammatory response. This phenomenon could increase sST2 levels, and will keep increasing in severe inflammatory condition such as pre-eclampsia. Thus, determining the baseline of sST2 level in third trimester of pregnancy is essential Two groups, which consist of normal pregnancy and pre-eclampsia group, was formed. All of this study samples were taken from third trimester of pregnancy and exclude those with a history of allergic, inflammatory and malignancy disease. We enrolled 30 samples for each group and a single blood sample was taken. Maternal plasma of sST2 was measured using the PresageÒ ST2 Assay according to the manufacturer’s instruction and the data will be analyzed using SPSS 23. Pre-eclampsia group was significantly (p=0.01) older than those in normal pregnancy. Blood pressure, both SBP and DBP, was significantly higher (p<0.001) in pre-eclampsia group. sST2 levels in pre-eclampsia group (mean 85.89 ng/ml) was also significantly higher (p<0.001) than those in normal pregnancy group (mean 38.3 ng/ml).