Original Articles
Shravan Kumar Nanumala
Abstract
In the study designed to investigate the neuroprotective activity of Cassia auriculata in experimentally induced Parkinsonism. Experimentally induced parkinsonism by administering the haloperidol in either short term and long term model to observe changes in catalepsy and in behavioral parameters like mucle rigidity as measured using rota-rod test and Spontaneous loco motor activity measured using actophotometer test and studying the antioxidant properties. The results showed that polyphenols, flavanoids, tannins, saponins and alkaloids were presented in the Ethanolic extracts of Cassia auriculata leaves. These extract has antioxidant properties. In addition, the treatment with extract significantly showed anticataleptic action as well as reduction of muscle rigidity and increase the Spontaneous locomotor activity. It is concluded that the extract has antioxidants activity combat against oxidative stress induced progressive neurodegeneration and dopaminergic activity; might be responsible for the antiparkinsonism activity by modulation of central neurotransmission.