Original Articles
Durgavati Yadav, Amit K. Sharm
Abstract
Acute kidney injury (AKI) is a severe threat to the modern drug treatment. There are only few drugs which are in clinical practice to revert the process of acute nephropathy. In Ayurveda, an ancient Indian system of medicine, several plants are designated for repair of kidney abnormalities but enough experimental data are not available. Here we have explored the nephroprotection of six such important medicinal plants. Water decoction of Crataeva nurvala, Pueraria tuberosa, Pterocarpus santalinus, Albizzia lebbek, Boerhaavia diffusa and Tribulus terrestris were standardized. AKI was induced by injecting cisplatin (6mg/kg BW, ip). Drug dose (50 mg/100 g BW, each) was given orally for five days to cisplatin induced AKI rats. On the 5th day urea, creatinine, creatinine clearance, lipid peroxidation and antioxidant status were measured in AKI rats. On 10th day following parameters in treated groups were determined and comparisons were drawn. Treated groups have reached the normal values of superoxide dismutase and catalase. Antioxidant properties were further correlated with reducing potential, tannins, flavonoids and phenolic content of the fraction; verified by Thin Layer Chromatography. Present investigation suggests that the water decoction of the selected herbals had shown significant protection against cisplatin induced AKI.