Naringin Attenuates DMBA-Induced Mammary Carcinogenesis in Rats via Regulating the Oxidative Stress and Antioxidants Status

Gopikrishnan Mani, Madankumar

Abstract

The present study was aimed to investigate the antioxidant and anti-carcinogenic efficacy of naringin on DMBA-induced mammary carcinogenesis in Sprague Dawley (SD) rats. Female SD rats were induced orally with a single dose of DMBA (80 mg/kg b.wt). Naringin (30 mg/kg b.wt. twice a week) was orally administered before and after tumor induction for 16 weeks. The levels of serum tumor markers viz. CEA, AFP and CA 15-3 were quantified by ELISA method. Biochemical analysis showed that serum LPO, NO, AST, ALT, ALP, ACP, LDH, 5'ND and GGT were increased while enzymatic and non-enzymatic antioxidants were significantly (P