Morbidity of Diabetes Mellitus in Cynomolgus Monkeys

Saimei Yan, Ting Wang, Chan

Abstract

Object: To determine the morbidity of diabetes mellitus in cynomolgus monkey by performing the Oral Glucose Tolerance Test (OGTT). Method: OGTTs were performed in 600 male cynomolgus monkeys, aging 4-18 years. The values of plasma glucose (PG) and insulin (Ins) were detected. Result: Significant differences were found in the values of PG and Ins among groups with different ages. The values of PG of 4 pathological courses of DM were: Normal glucose tolerance (NGT) group: Fasting plasma glucose (FPG) < 6.10 mmol/L and 2hPG < 7.8 mmol/L; Impaired fasting glucose (IFG) group: 6.10 mmol/L ≤ FPG < 7.0 mmol/L and 2hPG < 7.8 mmol/L; Impaired glucose tolerance (IGT) group: FPG < 7.0 mmol/L and 7.8 mmol/L ≤ 2hPG < 11.1 mmol/L; diabetes mellitus (DM) group: FPG ≥ 7.0 mmol/L or 2hPG ≥ 11.1 mmol/L. The morbidity of diabetes mellitus in the tested cynomolgus monkeys was 11.5%. Conclusion: Our findings pave the ways for a wide range of screening of DM in cynomolgus monkeys. Meanwhile, we also provide the reference to preclinically test new antidiabetic drugs in cynomolgus monkeys.