Original Articles
Sutha Shobana, Jeyaprakash Dha
Abstract
The coordinating character of 5-Fluorouracil (5-FU) (A) in the presence of some amino acid moieties (B ) [B = alanine (ala) and phenylalanine (pal)] with N and O sites towards some metal ions namely Ni(II), Cu(II ) and Zn(II) of MAB type mixed ligand complexes have been synth esized and characterized by elemental, spectral (vi brational, electronic, 1 H NMR and ESR) data as well as by magnetic moment v alues and conductivity measurements. The elemental analysis suggests that the stoichiometry of the Metal:5-FU(A):ala/pal(B) mixed ligand comple xes to be 1:1:1. The low molar conductance values reveal the non-electrolytic nature of these complexes. Magneti c moment values in concert with the electronic spectra indic ate that 5-FU coordinates with the metal ion in a b identate manner through the C (4) = O and N (3) atoms also identify that the amino acids behave a s bidentate by nitrogen and carboxylato oxygen. The antimicrobial activity of t he synthesized complexes also is screened against b acteria and fungi. Cu(II) and Ni(II) mixed ligand complexes show an in creased activity in comparison to the controls.