Microwave Irradiated Convenient Synthesis of 1, 2, 3, 4-Tetrahydropyrimidine-5-Carbonitrile Derivatives

Kavitha Siddoju

Abstract

A multicomponent reaction involving one-pot reaction of ethylcyanoacetate, Urea and arylaldehydes in presence of p-TSA, reflux or MWI. Aldehyde (3 mmol), ethyl cyanoacetate or phenyl acetic acid (3 mmol), urea (4.5 mmol) and p-TSA were mixed by stirring in a 25 mL round bottom flask for specified time at a temperature of 70°C, reflux for 7-9 h or MWI with 6-8 mins. (Scheme I). The products were further confirmed by spectral analysis data.