Microwave assisted synthesis of Isoflavones

R. B. Kshatriya, Y. I. Shaikh

Abstract

Isoflavones are phenolic natural products occur in nature in plants, they are secondary metabolites. They are molecules of flavonoid family. Isoflavones are derived from 3-phenylchromen-4-one. They possess diversified biological activities. Therefore, various organic/medicinal chemists around the world have developed various synthetic routes methodologies to achieve the target molecules. We wish to report here with a green approach. In our methodology Deoxy benzoin was obtained by treating a substituted phenol with phenyl acetic acid in presence of BF3etherate as a Lewis acid. This intermediate in presence of Vilsmeir reagent and DMF was cyclized under microwave to furnish the product in good yield.