Microwave assisted synthesis of 6-methyl-1,2,3,4-tetrahydro-N-aryl- 2-oxo-4-arylpyrimidine-5-carboxamide and 3, 4-dihydropyrimidin- 2(1H)-ones under solvent free conditions

I. T. Phucho, S. Tumtin, A. No

Abstract

6-Methyl-1,2,3,4-tetrahydro-N-aryl-2-oxo-4-arylpyrimidine-5-carboxamide and 5-unsubstituted 3, 4-dihydropyrimidin-2(1H)-ones have been synthesised from three component cyclocondensation of N-aryl-3-oxobutanamide/acetophenone, aldehyde and urea /thiourea in presence of PTSA under solvent free microwave irradiation.