Kinetic spectrophotometric determination of cefadroxil in pure substance and pharmaceutical dosage form

Mykola Ye. Blazheyevski and Yu

Abstract

A simple, reliable and sensitive kinetic spectrophotometric method was developed for determination of cefadroxil in pure substance and dosage form by the product of two conjugate reactions of peroxoacidic oxidation and perhydrolysis in a basic medium using potassium peroxomonosulfate as analytical reagent (KHSO5). The initial rate method was used at 294 nm. Linearity was studied over concentration range 1-7 m mL-1 and correlation coefficient was found to be 0.999 for regression line. The proposed method was validated statistically and checked through recovery studies. Statistical comparisons of the results with the reference methods show excellent agreement and indicate no significant difference in accuracy and precision.