Sara S AbouZekry
Abstract
Honey, pomegranate peel extract (PPP) and bee venom (BV), were used in combination with polyvinyl alcohol (PVA) to develop a novel nanofibrous wound dressing. Methanolic PPP was prepared and mixed with either manuka honey (MH) or lyophilized multiflora honey powder (LH) together with BV to have a total of three formulas: MH/PPP, MH/PPP/BV and LH/PPP/BV. The formulas were tested for their antibacterial activity, cytotoxicity, and wound healing activity in an excisional wound rat model. Scanning electron microscopy showed that LH fibers had smaller and more uniform diameter than MH fibers. Moderate swelling and higher weight loss capacities were detected when compared to PVA mats. Antibacterial tests showed significant antibacterial activity against S. aureus and E. coli compared to negative controls (P < 0.0001). No cytotoxicity was observed. In vivo wound mending study demonstrated that all treatment bunches upgraded twisted recuperating as appeared by expanded injury conclusion rates contrasted with negative benchmark groups at days 3, 5 and 10 (P < 0.0001), and histological assessment. In comparison to treatment groups, Medihoney® calcium alginate dressing significantly enhanced healing compared to negative controls at days 3 and 5. However, healing was delayed afterwards. These results indicate that MH/PPP/BV nanofibres are promising for wound healing. The effective treatment of wounds remains a major challenge for global health. Failure to heal or lengthen the wound healing process results in increased financial and social stress for healthcare facilities, caregivers, patients and their families. The occurrence of various forms of wounds such as chronic and acute wounds, pressure ulcers, venous stasis ulcers and diabetic ulcers has increased over the years in most countries, especially developed countries where the expectation life has increased over time and is accompanied by geriatric diseases. . Acute and chronic non-healing wounds impose heavy financial and quality of life burdens on patients [1]. Chronic wounds are normally characterized by severe pain, infection, loss of function and loss of mobility and can lead to amputations and, in some cases, even death. With an increase in the prevalence of wounds and the high cost of orthodox medicines, most patients, especially those from developing countries, resort to herbal preparations or remedies which are reputed to be readily available and good. market for their treatment. The urgent need to identify effective, safe and cost-effective wound healing promoters that can be introduced into clinical practice is unequivocal [2, 3]. This has resulted in an increased search for powerful and cost-effective healing agents from natural products, including herbal remedies. Herbal remedies have been used in the management of various diseases since ancient times. It is estimated that around 70-80% of the world's population depends on plant-based medicines for the treatment of disease. The use of herbal medicines in the management of acute and chronic wounds is common in most traditional medicine practices around the world. On this basis, many plants from tropical and subtropical regions of the world were examined for their healing activity. However, there are still many herbal remedies that need to be screened for in the search for newer, effective and cost-effective healing agents. This special issue provides the platform to highlight recent efforts in this regard. This issue contains eight articles that emphasis on concentrates on current patterns in wound administration and related confusions, new characteristic items, including creature items, and/or detached mixes with mending acting R. Komakech et al. presented a review of the healing potential of Aspiliaafricana (Asteraceae), a plant used in traditional African medicine to treat wounds. The authors reported that in vitro and in vivo studies have provided evidence of the wound-healing properties of plant-derived extracts and phytochemicals, including alkaloids, saponins, tannins, flavonoids, phenols, terpenoids , β-caryophyllene, germacrene D, α-pinene, hull, phytol and linolenic acid. These phytoconstituents were linked to a strong anti-inflammatory, antimicrobial and antioxidant activity, all essential for wound healing. The specific activities of extracts from A. Africana and its beneficial constituents for wound healing have been reported to include inhibitory effects on bleeding, improved wound contraction, increased levels of basic fibroblast growth factor (BFGF) and platelet-derived growth factor, and stimulation of hematological parameters such as white and red blood cells.