Isolation, Characterization and Cytotoxic Activity of Isolated Compounds from Seed of Carapa angustifolia (Meliaceae)

Mafo Fokam MA, Munvera Mfifen

Abstract

Phytochemical investigation on Carapa angustifolia, an endemic Cameroonian Meliaceae species, led to the isolation and characterization of four andirobin-type limonoids, known as methyl angolensate (1), andirobin (2), 7-deacetoxy-7-oxogedunin (3) and 7-deacetoxy-7-hydroxygedunin (4) together with six known compounds. The structures of these compounds were identified by NMR and MS spectroscopic data and by comparison of these data with those reported in literature. The compounds 1-10 are reported for the first time from C. angustifolia. The cytotoxic activity of some compounds has been evaluated and the chemotaxonomic significance of isolated compounds has also discussed.