Inhibitory interactions of Coenzyme Q10 with selected key enzymes of glucose metabolism: An in silico approach

Udhaya Lavinya B., Giridharan

Abstract

Loss of glycemic control plays an important role in the induction of short and long term diabetic complications that have a wide prevalence around the globe. Hence, it is necessary to explore the effectiveness of synthetic and natural compounds as inhibitors of key enzymes in diabetes. The aim of current study is to screen the in silico inhibitory activity of CoenzymeQ10on enzymes such as human xanthine oxidoreductase, human glycogen synthase kinase 3-β, α-glucosidase, human aldose reductase and alpha amylase. Docking experiments were carried out on Patch Dock server and the docked complexes were analyzed using PyMol molecular viewer. The in silico experiments revealed that Coenzyme Q10 showed 3 hydrogen bond interactions with human glycogen synthase kinase 3 beta (PDB Id.:3SAY) which is an important target in the treatment of obesity-associated insulin-resistance in type 2 diabetes.