Inhibitory effects of phenolic compounds from stems of Acer ginnala on nitric oxide production

Eun-Kyung Ko and Sun-Eun Choi

Abstract

Activity guided isolation of 80% acetone extract from the barks of Acer ginnala Maxim. yielded five gallotannins[6- galloyl-1,5-anhydroglucitol (ginnalin B) (1), acertannin (3,6-digalloyl-1,5-anhydroglucitol) (2), methyl gallate (3), acertannin(2,6-digalloyl-1,5-anhydroglucitol) (4) and gallic acid (5)].In order to evaluate the anti-inflammatory effects of these compounds, their inhibitory activities agains tnitric oxide production in lipopolysaccharide(LPS)- stimulated RAW 264.7 cells were examined