Value Added Abstracts
Dariush D. Farhud
Abstract
the increase rate of infertility, the referral rate to infertility treatment centers has also increased. Nowadays, assisted reproductive technology (ART) is used to treat this problem. Considering the possible future implications for mothers who are treated with in-vitro fertilization (IVF) and the offspring as the end product of this method, extensive researches have been conducted in this regard. According to some researches, there is speculation about the increased risk of cancer in mothers and their offspring. In in-vitro fertilization (IVF), drugs such as Clomiphene citrate and gonadotropins are used to stimulate and mature follicles and thus increase ovulation. Based on studies, the long-term use of these drugs can increase estrogen hormones and cause excessive expression of genes, resulting in an increased risk of breast cancer. Breast cancer is one of the most common cancers among women, which is mostly hereditary and afflicted with high and growing severity. In this article, we are referring to and collecting more than one hundred articles worldwide, which followed the hypothesis that the use of IVF drugs can lead to breast cancer, and our findings completely confirm this. With this in mind, mothers who are going to have infertility treatments should be individually evaluated “personalized medicine” and family history of breast cancer, must be considered prior to treatment.