In vitro antioxidant potential study of triazole and thiadiazole analogues

M. Al-Ghorbani, V. Lakshmi Ran

Abstract

The synthesis of 3-(2-aroylaryloxy)methyl-5-mercapto-4-phenyl-4H-1,2,4-triazole analogues (6a-e) and 2-(2- aroylaryloxy)methyl-5-N-phenylamino-1,3,4-thiadiazole (7a-e) were reported earlier. The antioxidant properties of these compounds 6a-e and 7a-e were evaluated by DPPH, nitric oxide and hydrogen peroxide radical scavenging methods. The investigation of antioxidant screening revealed that some of the tested compounds showed good to moderate antioxidant activity. Interestingly, the results show that the compounds containing electron releasing groups like methyl and methoxy exhibit good activities. In the above set of compounds 7e, 6e and 6d have shown very good antioxidant activity.