Research Article
V.K. Meenakshi*, M. Paripooran
Abstract
Immunomodulatory activity of the ethanol extract of Phallusia nigra was evaluated against Dalton’s Lymphoma Ascites (DLA) cells on Swiss Albino mice. After tumor inoculation the extract at the dose of 50, 100 and 150 mg/kg body weight were injected intraperitoneally and compared with the standard drug Vincristin (0.08 mg/kg body weight). Administration of the extract increased bone marrow cellularity (27.38×106 cells/femur) and β-esterase positive cells (1375/4000 cells). The antibody titer was maximum (247.68±3.19) in Group IV on the 12th day of treatment. Plaque forming cells in spleen increased gradually reaching a peak (169.93×106) on the 6th day. A reduction in the serum Gamma Glutamyl Transpeptidase (GGT), cellular Glutathione (GSH) and restoration of NO levels was observed on the 15th day in tumor bearing mice. The results indicate that the extract contains bioactive compounds playing important role in immune response.