Original Articles
Zarif Mohamed Sofiana, Jafri M
Abstract
The possible formation of a host-guest complex between levodopa and HP-β-CD was studied accordingly. A simple phase-solubility study was conducted based on the method proposed by Higuchi and Connors. The complexation constant (Kc) calculated was 30.53 M-1. An improved solubilty of levodopa was achieved as a result of complex formation with HP-β-CD. From the 1H-NMR data, upfield shifts in all HP-β-CD protons were observed. In particular, we found that Δδ H3 > Δδ H5 and this finding suggests that partial inclusion has been formed between levodopa and HP-β-CD. SEM images revealed distinct morphological images between the starting materials and the complex. Our data were all in great agreement which evidenced the formation of HP-β-CD/levodopa.