Histamine H2-receptor antagonist imprinted-poly (vinylimidazole) grafted multiwalled carbon nanotubes

Sooraj M. P. and Beena Mathew

Abstract

Functionalised surfaces of multiwalled carbon nanotubes were used for grafting cimetidine, a histamine H2-receptor antagonist, imprinted poly(vinylimidazole) onto the nano matrix. Fourier Transform-Infrared spectroscopy, Powder X-ray Diffraction studies, Thermogravimetric Analysis and Scanning Electron Microscopy were used for the characterisation of the product. Different parameters affecting the rebinding process like initial template concentration, time of contact, mass of sorbent etc. were optimised. The nanosorbent exhibited excellent homogeneity as indicated by its high regression coefficient value (R2 = 0.999) for Langmuir adsorption isotherm model. Selectivity studies further demonstrated the successful fabrication of template-specific cavities on the surface of the nanosorbent.