Green synthesis of 1,4-disubstituted 1,2,3-triazoles and their antibacterial activity

Suresh Seeka, Sirassu Narsimha

Abstract

A facile and highly efficient green synthesis of 4-((1H-imidazol-1-yl)methyl)-1-phenyl-1H-1,2,3-triazole(1a-1f) and 4-((1H-pyrazol-1-yl)methyl)-1-phenyl-1H-1,2,3-triazole(2a-2f) in good to excellent yields from in-situ-generated alkyne with aryl azides by Cu(I)-catalyzed cycloaddition reaction. The reaction proceeds smoothly in a mixture of [BMIM][PF6] and water at room temperature without any additive. All the synthesized compounds were characterized by spectral studies and screened for their in vitro antibacterial activity.