Research Article
Rakesh Pahwa, Sanjay Kumar, Ni
Abstract
Various attempts have been made globally in the development of gastroretentive dosage forms to overcome physiological adversities, such as short gastric residence time, unpredictable gastric emptying time etc. These dosage forms can be retained in the stomach for prolonged period of time in a predetermined manner. Among various gastroretentive techniques, floating drug delivery system is one of the promising approaches providing local delivery to the stomach and proximal small intestine revealing better bioavailability, improved therapeutic activity with substantial benefits for patients. This manuscript outlines the potential applications of gelucire in the design of floating drug delivery systems. Owing to its various beneficial properties, it is a favoured candidate for utilization in the floating dosage forms. Several recent attempts and advanced approaches exploiting gelucire as a potential carrier in the development of gastroretentive floating dosage forms have been discussed.