Original Articles
Mohamed A. El-Nabarawi, Ehab R
Abstract
The aim of the present study was to formulate topical gel containing baclofen niosomes. Baclofen is a direct agonist at GAPAB receptors with an anti-inflammatory effect. Baclofen has narrow therapeutic index and many gastrointestinal side effects. The current market products of baclofen are intrathecal injection and oral tablets which cause many problems after their administration, Thus, niosomal formulations as carriers for the topical delivery of baclofen will prolong the contact time and increase the permeability through the skin so improve its, as anti-inflammatory. The baclofen niosomes were prepared by altering the ratios between various non-ionic surfactants (Span 60, 40), cholesterol and charge inducing agents using thin film hydration method, the prepared niosomal formulations were evaluated for their encapsulation efficiency and maximum entrapment efficiency attained a maximum value of 80.31%, and characterized by transmission electron microscopy, differential scanning calorimetry, particle size analysis, zeta potential analysis and in vitro release after 24 hours. The maximum cumulative release percentage was between 65.55%. Two gelling agents were used for the preparation of various baclofen gels and baclofen niosomal gels, in vitro permeation studies. Our results suggested that the niosomal delivery of baclofen in carbopol gel base acts as a suitable topical drug delivery system.