Research Article
Vinay Wamorkar, Pendota San
Abstract
In present investigation the sustained release matrix tablet of naproxen was formulated to study effect various grades of HPMC and insoluble filler. The model is based on a novel dosage form designed to deliver a drug into the gastrointestinal tract in a controlled manner. Matrix tablets were prepared by wet granulation method. As a pre-requisite and part of pre-formulation studies, drug along with selected excipients and as optimized formulation was subjected to FT-IR studies. It was found that no interaction among excipients occurred, as no extra peaks obtained. Tablets were evaluated for various IP-QC tests like hardness, friability, content uniformity, physical appearance and in-vitro release by USP paddle apparatus. Model equations of zero and first order,Higuchi, Hixson-Crowell and Peppas,intended to elucidate the drug release mechanism, were fitted to the release data. Mathematical modeling of in-vitro dissolution data indicated the best-fit release kinetics was achieved with firstorder release kinetics with r2 vales of 0.915, which evidenced that the formulations are useful for a controlled release of naproxen. Simultaneously, from Hixson-Crowell equation shape dependency was also studied with r2 values of 0.973. By Peppas equation the value of r2 for optimized formulation was found to be 0.563and for n value of 0.603. This indicates the release from formulated tablet follows Non-Fickian release mechanism.