Research Article
Manish R. Bhise, Sandip B. Sap
Abstract
The objective of present study is to develop the mouth dissolving tablet of an antihypertensive drug, Olmesartanmedoxomil. Mouth dissolving tablets of Olmesartanmedoxomil drug were prepared by using three different superdisintegrants like Cross carmellose sodium, Sodium starch glycolate and Crospovidone. The method of tablet preparation is direct compression method and evaluated for physicochemical evaluation parameter such as hardness, friability, weight variation, drug content uniformity, water absorption ratio, wetting time, invitrodisintegration time and in-vitro dissolution studies.In the present study, it was proved that the formulations containing Crospovidone have shown good in-vitro results compared to other formulations. However the formulations containing 8 % w/w concentration of any superdisintegrants have shown better optimum results, hence selected as best formulations in this study.Formulation F8 has shown excellent results in water absorption ratio. Hence F8 batch containing 8% cross povidone was found to be an optimized batch.