Research Article
Pravin Uttekar, Akshata Kulkar
Abstract
The absorption of drugs via transdermal route improves the bioavailability of drugs that could have might otherwise been metabolized by first-pass way (pre-systemic drug elimination) by gastrointestinal tract. Drug absorption is mainly through passive diffusion through the lipoidal membrane. Thus TDDS have attracted the attention worldwide for optimizing the drug delivery. The aim of the present research is to formulate matrix type TDDS which contains the drug captopril using hydroxy propyl methyl cellulose E-15(HPMC E-15), Eudragit RS 100 as a release controlling polymers. The formulated patches were characterized by diffusion studies. The work was aimed to develop the TDDS which controls the release of captopril up to max time period.