Research Article
M. Harikrishna, Rajesh Akki, M
Abstract
The present study was to develop a bilayer floating tablet for Atenelol and Carvedilol using direct compression method. Bilayer floating tablets were designed to prolong gastric retention time and increase the bioavailability of the drug. Bilayer floating tablets made up of two layers, immediate release layer and controlled release layer. Immediate release layer contains sodium starch glycolate as a super disintegrating agent and controlled layer contains carbapol934p grade polymers and Ethyl cellulose as controlled release polymers .Sodium bicarbonate is used as a gas generating agent. The tablets were evaluated for physico-chemical properties such as bulk density, tap density, hausners ratio, hardness, thickness, friability, drug content, floating lag time, floating duration in vitro drug release by dissolution studies and stability studies . FT-IR studies revealed that there was no interaction between the drug and polymer used in the study. The optimized tablets B12 showed controlled and complete drug released 99.95% over a period of 24 hrs. And it follows zero order release and non-Fickian diffusion.