Flavonoids from Thymus numidicus Poiret

Research Article

Feryal Benayache, Ahcene Boure

Abstract

Phytochemical investigation of the dichloromethane, ethyl acetate and n-BuOH soluble parts of the aqueous-EtOH extract of the aerial parts of Thymus numidicus Poiret led to the isolation of circilineol 1, circimaritin 2, apigenin 3, luteolin 4, apigenin 7-O-b-glucuropyranoside 5 and luteolin 7-O-b-glucopyranoside 6. The structures were established by spectral analysis including HRESI-MS, UV and 2D NMR experiments (COSY, ROESY, HSQC and HMBC) and comparison with literature data. To the best of our knowledge compounds 1, 2, 5 and 6 were described for the first time from this endemic species. n-BuOH extract showed moderate scavenging effect against DPPH .

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