Facile synthesis of some new maleamic acid and maleimide derivatives of 1,3-thiazoles

Hemanth Hegde, Vachan Kumar Sh

Abstract

Some new maleamic acid derivatives of thiazoles (2a-e) and their maleimide derivatives (3a-e) were efficiently synthesized. The maleimide derivatives were synthesized using both the conventional method and microwave irradiation technique where it has been found that the microwave supported syntheses is more efficient than the conventional heating method. The precursor’s substituted aminothiazoles (1a-e) were prepared by employing the solvent free conditions. The structures of all the compounds were ascertained by spectral and analytical data.