Original Articles
Oluyemisi Adebowale Bamiro, Ad
Abstract
This study aims at evaluating the disintegrant properties of Terminalia randii gum at various concentrations in Paracetamol tablet formulation in comparison with a standard disintegrant (corn starch) using wet granulation method. The mechanical properties of the tablets were assessed using crushing strength and friability while the release properties were assessed using the disintegration and dissolution times. Data were analysed using ANOVA. The crushing strength of formulations containing corn starch was observed to decrease with increase in disintegrant concentration, while those containing terminalia gums was observed to increase with increase in concentration. Formulations containing Terminalia randii gum generally had lower mechanical strength at lower concentrations and significantly (P<0.001) higher disintegration times than those containing corn starch. The disintegration time was observed to be within fifteen (15) minutes specified for uncoated tablets. The time taken for 50% dissolution (T50) of formulations containing corn starch was significantly (P<0.05) lower than that of formulations containing terminalia gum but there was no significant difference in the T90 of the formulations. The results show that Terminalia randii gum compared favourably with official corn starch and it could serve as an alternative disintegrant in tablet formulations.