Evaluation of Excipient Potentials of Alpha Cellulose Extracted from Rice Husk in Metronidazole Compressed Tablets: Colon Targeted Drug delivery and In Vitro Characterizations

Ugwu CE, Chime SA and Isha CE

Abstract

The objective of this research demonstrates the excipient potential of alpha-cellulose in metronidazole tablet. Direct compression method was adopted. Powder and tablet properties of the α-cellulose were characterized, evaluated with FTIR, micromeritics, drug content, quality control tests, in vitro drug release and in vitro antimicrobial studies, and the results compared to MCC and Kollidon® VA 64. Chemically, their constituents are almost identical in FTIR study and compatible with API. Batch A powder exhibited a significant good flow property (p