Original Articles
Camilla Pinheiro de Menezes, A
Abstract
Combining antifungal drugs may improve therapeutic response. The potential benefits of using therapeutic combinations include a broader spectrum of efficacy, improved cure rates, safety, and tolerability, reduction of resistance to antifungal drugs, dose reduction, and thus reduced toxicity. The research aimed to study the antifungal properties of citral associated with synthetic antifungal (Amphotericin B and Voriconazole) against strains of Cladophialophora carrioni and Cladosporium spp. The parameters used for this purpose were based on the determination of Fractional Inhibitory Concentration (FIC) Index (Method of association – Checkerboard). The study shows that citral in combination with voriconazole an indifferent effect, and resulting in a FIC index varied between 1.5-3.0. However, the combination of the citral and amphotericin B showed FIC index varied between 6.0-8.0, for four species tested, obtained antagonistic effects. This study contributes to understanding the citral’s antifungal activity associated with antifungals agents against dematiaceous fungi. However, more studies are needed to investigate whether citral interations with drugs.