Original Articles
Naveen Alasyam, Mannala Sunil,
Abstract
Epilepsy is a central nervous system disorder(neurological disorder)in which the nerve cell activity in your brain is disturbed, causing a seizure during which you experience abnormal behavior, symptoms and sensation including loss of consciousness. The present study was performed to evaluate the anti – convulsant activity of alcoholic extract of Mimosa pudica (Mimosaceae) against the MES-Induced Seizures. A total of 30 Swiss albino rats were divided into five groups containing six in each. Group I – Control Rats (Normal saline 25 ml/kg), Group II – Standard (Phenytoin 25 mg/kg), Group III – AEMP 50 mg/kg, Group IV – AEMP 100 mg/kg, Group V – AEMP 200 mg/kg. Maximal electroshock seizures (MES) in albino rats were used to study anticonvulsant activity of alcoholic extract of Mimosa pudica. Alcoholic Extract of Mimosa pudica exhibited a significant (P<0.00) dose dependent protection against tonic extensor phase at all tested doses (50, 100 and 200mg/kg ), with maximal effect seen in higher dose (200 mg/kg).