Short Communication
Alissandra de Moura Gomes
Abstract
Osteogenesis imperfecta (OI) is an inherited connective tissue sickness characterized via fragility, deformity and low bone density, as well as by other scientific manifestations. Type I OI is the mildest and most commonplace form of the disease, caused by mutation inside the COL1A1 gene, resulting within the production of handiest ~50% of everyday collagen. The corresponding animal model is the oim mouse, supplying a phenotype very just like human kind I OI. We intention, for the first time, at comparing the electrotransference of mouse increase hormone (mGH) gene, encoding a protein that already confirmed therapeutic effects, collectively with the administration of murine mesenchymal stem cells (MSCs), for enhancing heterozygous oim mice phenotype