Research Article
Reetu Toppo, B.K.Roy and Anil
Abstract
The pharmacokinetic studies of enrofloxacin was conducted in eighteen turkeys (1 to 1.5 years age) weighing between 3 to 4 kg following single i.v. dose (10 mg/kg b.w.) alone and with meloxicam (1 mg/kg b.w.). Quantitative estimation of enrofloxacin and meloxicam was done by high performance liquid chromatography. The maximum concentration of drug in plasma (Cpmax) of enrofloxacin with meloxicam (8.42 ± 0.40 μg/ml) was not significantly different from that of enrofloxacin alone (9.68 ± 0.44 μg/ml). Pharmacokinetic parameters of enrofloxacin alone (C°p =10.38±0.43 μg/ml, t½β =2.73±0.12 h, MRT = 3.65±0.21 h, ClB =8.41±0.66 ml/kg/min, Vdarea =1.95±0.08 L/kg) as compared to when it was administered with meloxicam ( C°p =9.35±0.62 μg/ml, t½β =2.70±0.13 h, MRT =3.73±0.18 h, ClB =9.79±0.84 ml/kg/min, Vdarea =2.26±0.15 L/kg) in turkeys did not differ significantly. The t½β of meloxicam with enrofloxacin (2.50±0.08 h) was significantly shorter as compared to meloxicam alone (3.03±0.18 h). Based on pharmacokinetic studies ENR may be injected at dose rate of 4.5 mg/kg i.v. at an interval of 20.38 h in turkeys.