Research Article
Sirisha Yella, Gopala Krishna
Abstract
The aim of present study is to determine the effect of various diluents and super disintegrants in various ratios on drug release of Almotriptan. Triptans are widely used for the treatment of migraine. Almotriptan is freely water soluble and has a bioavailability of 20% due to its high hepatic first pass metabolism. So orally disintegrating tablets of almotriptan have been developed to increase the bioavailability of the drug using optimization technique and effect of various excipients have been studied to obtain an optimized formulation. Diluents, microcrystalline cellulose, spray dried lactose, mannitol and starch were employed and superdisintegrants, cross povidone, cross carmellose sodium & sodium starch glycolate were used in different ratios. All the tablets were evaluated for precompression and post compression parameters. All the precompression parameters were found to be satisfactory. Among all the formulations F23having mannitol as diluent & SSG (8%) as superdisintegrant has shown maximum drug release of 100.03% within 20min whereas the marketed formulation shows release of 89.97%. The drug release from the optimised formulation followed first order kinetics.