Fahar Ibtisham, JinJun Chen, Y
Abstract
Aspirin (Acetylsalicylic acid) is widely used in human and veterinary as anti-inflammatory ， cardiovascular prophylaxis, anti-clotting agent and to decrease cancer risk. However, it is often mis- or over-consumed, including in population subgroups, such as elite athletes, to prevent pain and treat injuries. Many risks associated with its usage have been reported but there is a deficiency of information about its affects on androgenic studies, histology of the testes, kidneys, livers and reproductions. In this paper we tried to collect the information about it deleterious toxicity effects on male rat reproduction. The literature findings showed that Aspirin deadly affect the production of sperm and reproductive hormones; in-addition decreases the testicular weight and also affect the blood profile. Effect of aspirin on the male reproductive system may be due to being a Prostaglandins inhibitor. While hepatic and renal toxicity further reveal aspirin deleterious toxic nature.