Ditolyldithiophosphates of titanium: Synthesis, characterization and in vitro antimicrobial and cytotoxic studies

Atiya Syed, Ruchi Khajuria, Sa

Abstract

Ditolyldithiophosphates of titanium corresponding to [(C5H5)2Ti{S2P(OAr)2}nCl2-n] (Ar = o-, m-, p-CH3C6H4, p-Clm- CH3C6H3; n = 1 and 2) have been synthesized and characterized by elemental analyses, IR, mass and heteronuclear NMR (1H, 13C and 31P) spectroscopic analyses. The combined DTA/DTG thermal analysis of [{(p- CH3C6H4O)2PS2}2Ti(C5H5)2] has yielded final thermolysis product as TiS2. Cyclic voltammetry probed the redox capabilities of [{(m-CH3C6H4O)2PS2}2Ti(C5H5)2]. Comparison of antimicrobial activity of the ligands and complexes has shown that the complexes are more effective than the ligands. The in vitro cytotoxic investigations against the cultivated human cell lines revealed that the titanium complexes are more active.