Dissolution Study of Oxolamine Citrate by UV Spectrophotometric Method in Pharmaceutical Dosage Form

Rele Rajan V.* and Sawant Swap

Abstract

Dissolution study was carried for oxolamine citrate tablets containing 100 mg of active pharmaceutical ingredient. After the determination of solubility, the conditions selected were paddle at 75 and 100 rpm, with 1000 ml 0.01N HCl and phosphate buffer at 37°C ± 0.5°C. Under these conditions, the in vitro release profiles of oxolamine uncoated 100 mg tablets shown good results. The drug release was evaluated by UV spectrometric method at 237 nm in zero order spectrum. The linearity was found between 50- 150% with coefficient of co-relation was 0.9996. The standard devotions and relative standard deviation of precision were 0.015 and 0.015% respectively. The dissolution test developed and validated for oxolamine tablets was considered satisfactory.