Research Article
Ashish Bhatt, Rajesh Kumar Sin
Abstract
Some 1-aryl-3-alkyl-4-substituted aryl (or heteroaryl)-5 amino pyrazole derivatives have been synthesized by the reaction of substituted aryl or hetero aryl acetonitrile with alkyl acetate( ethyl acetate or ethyl trifluoroacetate ) followed by reaction with phosphorous oxychloroide and further by cyclisation with substituted aryl hydrazine in presence of triethyl amine in ethanol . All the synthesized compounds were characterized by elemental analysis, 1H NMR and LCMS. These were screened for in-vitro antimicrobial activity against two gram positive (Streptococcus pyogenes and Staphylococcus aureus ) and two gram negative bacteria (Pseudomonas aeruginosa and Escherichia coli ) along with antifungal and antimalarial activity.