Development of sensitive spectrophotometric method for the determination of metoprolol in bulk and tablet form

M. Suman, C. Narasimha Rao, S.

Abstract

A simple procedure for the determination of metoprolol in bulk and tablet forms by spectrophotometry method was developed. The proposed method is based on the charge transfer reaction between the drug and chlorodinitrobenzene (CDNB) at room temperature in methanol. When metoprolol standard solution is allowed to react with CDNB, a yellow colour was observed which measured at λ max 425nm. Linearity is maintained within in a wide concentration range of 8-16μg/ml. The limit of detection and limit of quantitation are 0.1104 and 0.3678 respectively.The assay of results is in good agreement with label claim. Hence the proposed method is precise, accurate and useful for the regular quality control.