Research Article
Manish Kumar Thimmaraju, Kyath
Abstract
A simple, accurate, precise, specific and highly sensitive spectrophotometric method developed for the determination of Fluindione in bulk drug .The optimum conditions for the analysis of the drug were established. The λ max of the Fluindione was found to be 230nm in 10% methanol in 0.1N HCL. The method shows high sensitivity with linearity 1 to 5μg/ml. The regression of the curve was Y = 0.097x+0.1277.The apparent molar absorptivity was found to be 4.79x104mol−1 cm−1 in 10 % Methanol. The lower limit of detection and the limit of quantitation was found to be 0.09302μg/ml and 0.28186μg/ml respectively. All the calibration curves shows a linear relationship between the absorbance and concentration and correlation coefficient was 0.999.The proposed method will be suitable for the analysis of Fluindione in bulk form.