Original Articles
Alivelu Samala, Manala Sowmya,
Abstract
A simple, accurate, rapid and isocratic reverse phase high performance liquid chromatographic (RP-HPLC) method has been developed for estimation of Ropinirole hydrochloride in tablet dosage forms.Chromatographic separation was operated with 0.05mol glacial acetic acid (pH 3): acetonitrile (50:50v/v) at a flow rate of 1ml/min on hypersil C18 (BDS) column, using 250nm as detection wavelength. The retention time for Ropinirole hydrochloride was found to be 4.037min. The method was linear over the concentration range of 4-12μg/ml and coefficient correlation was found to be 0.997. The method showed good recoveries (99.0-99.89%) and its intraday and interday precision were found to be 0.39 and 0.479 respectively. For its sensitivity and reliability, the proposed method can be used for quality control assay of Ropinirole hydrochloride.