Original Articles
G Sivasankara Rao, S Venkat Ra
Abstract
New simple, accurate and economical UV-spectrophotometric method has been developed for estimation of valsartan in pure and pharmaceutical formulation. The λmax of valsartan in methanol and water was found to be 250.80nm. The drug exhibited the linearity in the concentration range of 5.0-30µg/ml with correlation coefficient of 0.996.The accuracy of the method was made by recovery experiment performed at three different levels i.e., 50%, 100% and 150 %. The % recovery was found to be in the range 99.26% - 100.7%. The low values of % R.S.D. are indicative of the high accuracy and reproducibility of the proposed method. The precision studies of the method revealed results of % R.S.D.values less than 2 indicating that the developed method is precise. The proposed method was applied to pharmaceutical formulation and % amount of drug estimated 99.97% was found in good agreement with the label claim. The developed method was a rapid and cost-effective for routine analysis of valsartan in pure and in pharmaceutical dosage form.