Development and validation of a HPLC/MS/MS method for the quantification of Cocaine and its principal metabolite

B. Belafkih, S. Belouafa, M. C

Abstract

A sensitive and fast HPLC/MS/MS method for measurement of cocaine in seized powders and of cocaine and benzoylecgonine in human urine was developed and validated. Good selectivity, linearity, accuracy and precision were obtained for the developed method. The validated method is very simple and more rapid than other similar methods.