Research Article
Rashmin S Thakor, Falguni D Ma
Abstract
Osmotic drug delivery systems are new approach for a controlled release dosage form. Nifedipine is a calcium channel blocker used in the treatment of hypertension. Nifedipine was selected as a model drug for investigation because it required 2-3 doses daily. So controlled release formulation is require. Controlled release of drug is achieved by adding a suitable polymer in dosage form. In present studied we prepared different dosage form using a Polyethylene oxide controlled release polymer. From the result it was cleared that higher concentration of water swell able polymer give optimum controlled release. Devices were prepared by two membrane thickness 110 μm and 340 μm. Nifedipine drug in osmotic tablet dosage form gives controlled release with 340 μm membrane thickness compare to 110 μm. Nifedipine drug release is similar from 250 μm and 510 μm diameter orifice size contained dosage form.