Design, synthesis and biological evaluation of novel diphenylthiazole-thiazolidin-4-one-based derivatives as anti-inflammatory/analgesic agents

Ahmed H. Abdelazeem, Mohammed

Abstract

A series of novel diphenylthiazole-thiazolidin-4-one-based derivatives was synthesized and characterized by elemental and spectral analysis. The newly synthesized compounds were screened for their analgesic and anti-inflammatory activities using acetic acid-induced writhing test and carrageenan-induced edema assay, respectively. Among the compounds, compound 13 was found to be the most potent analgesic and anti-inflammatory agent among the newly synthesized compounds compared to the standard drug, diclofenac.