Design and Synthesis of Novel (3-(2,2-Dihaloethenyl)-2,2-Dimethylcyclo-Propyl)(1H-1,2,4-Triazol-1-yl)Methanone Compounds with Fungicidal Activity

Rashmi S Sharma and Anita S Go

Abstract

Fungicide resistance has created a challenge for the agrochemical industry to discover and commercialize novel molecules or newer modes of action. Bearing in mind the characteristic indicators of the known Triazole fungicides, this study urged the synthesis of novel compounds. In the present study, the active 1,2,4-triazole moiety and the carbonyl group of 3-(2,2-dihaloethenyl)-2,2-dimethylcyclopropane carboxylic acids were combined to synthesize novel compounds. The structural data was elucidated on the basis of spectral and analytical data. These novel compounds were screened for their fungicidal activity. The results show promising antifungal activity displayed by these novel compounds.