Research
Rezk R. Ayyad, Ahmed M. Mansou
Abstract
In this work we synthesized 6,7-Dichloro-1,4-(2H,3H) phthalazinedione (I) [1] and its salt (II) which react with different alkylchloroacetates, afforded compounds III1-6. When reacted, the compound III2 with ammonia and different amines we obtained on IV and V1-7 respectively. The compound III2 also react with Hydrazine hydrated, result the compound VI, afforded compound (hydrazide) Hydrazied condensed with different aldehydes, we obtained on compounds VIII1-10. The compounds III1, III2, III3, III4, III5, IV, V1,V2, V3, VI, VII1, VII5, VII6,VII9, VIII1, VIII2, VIII7 and VIII8 tested as anticonvulsant against phenobarbitone as reference drug. The compounds III1-3, IV, V3, VI, VIII1,2 showed the most activity while the compounds V2, VII6,9 revealed moderate Introduction, finally compound VII5 was the lowest activity.