Cytotoxicity of Chitosan Oligomers Produced by Crude Enzyme Extract from the Fungus Metarhizium Anisopliae in Hepg2 and Hela Cells

Cristiane Fernandes de Assi

Abstract

Chitooligosaccharides exhibit biological activities, including antitumor, antimicrobial and antioxidant. In this study we used a mixture of chitooligosaccharides produced by enzymatic hydrolysis in two tumor cell lines and assessed the cell proliferation and cytotoxicity of these compounds. The proliferation of HeLa cells was inhibited around by 60%.