Cytotoxicity Analysis of Some Novel Pyrimidine Derivatives

D Durga Devi, S Manivarman, A

Abstract

Some pyrimidine derivatives are synthesized by one pot multicomponent condensation. All the compounds are characterized by FT-IR, NMR analysis. Anti-microbial activities of the synthesized compounds are evaluated by disc diffusion method, and results show that some of the compounds show good activity and the residual compounds show moderate activity. Toxicity of the compounds has been analysed by MTT assay using colo320 cell line.